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Controlled clinical trials involving protonix 10-, 20-, or 40-mg doses for up to 12 months, the following adverse events considered by investigators to be possibly, probably, or definitely related to drug occurred in 1 or more of gerd patients on long-term therapy.

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Absence of or decrease in body movements blindness blisteringpeelingor loosening of the skin bloating bloody or cloudy urine bloodyblackor tarry stools blurred vision chills clay-colored stools constipation continuous ringing or buzzing or other unexplained noise in the ears cough dark-colored urine decreased vision diarrhea difficulty with speaking difficulty with swallowing dizziness or lightheadedness drowsiness fast heartbeat feeling of constant movement of self or surroundings fever general feeling of tiredness or weakness greatly decreased frequency of urination or amount of urine headache hearing loss high fever hivesitchingor skin rash indigestion joint pain largehive-like swelling on the faceeyelidslipstonguethroathandslegsfeetor sex organs light-colored stools loss of appetite mood or mental changes muscle cramps muscle pain or stiffness muscle spasmstetanyor twitching pains in the stomachsideor abdomenpossibly radiating to the back pale skin puffiness or swelling of the eyelids or around the eyesfacelipsor tongue red skin lesionsoften with a purple center redirritated eyes seizures sensation of spinning sore throat soresulcersor white spots on the lips or in the mouth stomach paincontinuing swelling of the feet or lower legs swollen glands tightness in the chest trembling unexplained bleeding or bruising unpleasant breath odor unusual tiredness or weakness vomiting of blood yellow eyes or skin.

In patients with severe renal impairmentpharmacokinetic parameters for pantoprazole were similar to those of healthy subjects.

Tell your doctor if your condition persists or worsensThe risk of side effects goes up over timeAsk your doctor how long you should take this medication.

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