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Life-threatening disturbances of cardiac rhythmsuch as ventricular tachycardia and ventricular fibrillation leading to deathand rare reports of acute myocardial infarctionhave been reported within a few hours after administration of 5-HT1 agonists.

Imitrex will only treat a headache that has already begunIt will not prevent headaches or reduce the number of attacks.

Taking MAO inhibitors with this medication may cause a seriouspossibly fataldrug interactionDo not take any MAO inhibitorsisocarboxazidlinezolidmethylene bluemoclobemidephenelzineprocarbazinerasagilinesafinamideselegilinetranylcypromineduring treatment with this medicationMost MAO inhibitors should also not be taken for two weeks before treatment with this medicationAsk your doctor when to start or stop taking this medication.

Perform a cardiovascular evaluation in triptan-naive patients who have multiple cardiovascular risk factorse.gincreased agediabeteshypertensionsmokingobesitystrong family history of CADprior to receiving Imitrex tabletsIf there is evidence of CAD or coronary artery vasospasmImitrex tablets are contraindicatedFor patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluationconsider administering the first dose of Imitrex tablets in a medically supervised setting and performing an electrocardiogramECGimmediately following administration of Imitrex tabletsFor such patientsconsider periodic cardiovascular evaluation in intermittent long-term users of Imitrex tablets.

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